| 20. Jornada | 21.09.2021 | CD Guabirá | - | Club San José | 4:0 | ||||
| 22. Jornada | 20.10.2021 | Bolívar | - | Club San José | 4:1 | ||||
| 26. Jornada | 22.11.2021 | Club San José | - | Real Santa Cruz | 1:2 | ||||
| 28. Jornada | 30.11.2021 | Club San José | - | Oriente Petrolero | 0:2 | ||||
| 29. Jornada | 05.12.2021 | The Strongest | - | Club San José | 2:0 |  |
Bolivia