| 1. Jornada | 16.01.2022 | Alianza | - | Isidro Metapán | 0:2 | ||||
| 2. Jornada | 22.01.2022 | Jocoro FC | - | Alianza | 3:2 | ||||
| 3. Jornada | 27.01.2022 | Alianza | - | AD Chalatenango | 3:1 | ||||
| 8. Jornada | 20.02.2022 | Municipal Limeño | - | Alianza | 0:0 | ||||
| 9. Jornada | 23.02.2022 | Once Municipal | - | Alianza | 1:2 | ||||
| 10. Jornada | 27.02.2022 | Alianza | - | Atlético Marte | 3:2 | ||||
| 17. Jornada | 13.04.2022 | Alianza | - | Santa Tecla FC | 2:2 | ||||
| 18. Jornada | 17.04.2022 | Platense Zacatecoluca | - | Alianza | 0:1 |  |
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| 20. Jornada | 29.04.2022 | Alianza | - | Once Municipal | 1:0 | ||||
| 21. Jornada | 01.05.2022 | Atlético Marte | - | Alianza | 0:3 | ||||
| 22. Jornada | 07.05.2022 | CD Águila | - | Alianza | 3:1 |
El Salvador