| 7. Jornada | 26.08.2022 | MŠK Žilina | - | MFK Zemplín Michalovce | 2:0 | ||||
| 8. Jornada | 31.08.2022 | MFK Zemplín Michalovce | - | MFK Ružomberok | 1:1 | ||||
| 11. Jornada | 17.09.2022 | Zlaté Moravce | - | MFK Zemplín Michalovce | 0:1 |  |
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| 12. Jornada | 01.10.2022 | Dukla Banská Bystrica | - | MFK Zemplín Michalovce | 3:1 | ||||
| 13. Jornada | 08.10.2022 | MFK Zemplín Michalovce | - | Tatran Liptovský Mikuláš | 1:2 | |
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| 10. Jornada | 12.10.2022 | MFK Zemplín Michalovce | - | FK Železiarne Podbrezová | 1:0 | ||||
| 14. Jornada | 16.10.2022 | MFK Zemplín Michalovce | - | Slovan Bratislava | 0:1 | ||||
| 15. Jornada | 22.10.2022 | MFK Zemplín Michalovce | - | AS Trenčín | 2:0 | |
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| 18. Jornada | 12.11.2022 | MFK Zemplín Michalovce | - | MŠK Žilina | 3:2 | ||||
| 16. Jornada | 24.11.2022 | Spartak Trnava | - | MFK Zemplín Michalovce | 4:1 | |
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| 19. Jornada | 11.02.2023 | MFK Ružomberok | - | MFK Zemplín Michalovce | 1:0 | ||||
| 21. Jornada | 24.02.2023 | FK Železiarne Podbrezová | - | MFK Zemplín Michalovce | 2:2 | ||||
| 22. Jornada | 04.03.2023 | MFK Zemplín Michalovce | - | Zlaté Moravce | 0:0 |
Gambia