| 1. Jornada | 16.01.2021 | Danubio | - | Cerro Largo | 0:3 | ||||
| 2. Jornada | 21.01.2021 | Montevideo Wanderers | - | Danubio | 2:0 | ||||
| 3. Jornada | 31.01.2021 | Danubio | - | Peñarol | 0:1 | ||||
| 4. Jornada | 04.02.2021 | River Plate | - | Danubio | 0:4 | ||||
| 5. Jornada | 07.02.2021 | Danubio | - | Montevideo City Torque | 0:4 |  |
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| 10. Jornada | 28.02.2021 | Defensor Sporting | - | Danubio | 1:1 | ||||
| 11. Jornada | 07.03.2021 | Danubio | - | Liverpool | 0:1 | ||||
| 12. Jornada | 13.03.2021 | Danubio | - | Nacional | 2:1 | |
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| 13. Jornada | 19.03.2021 | Boston River | - | Danubio | 1:5 | |
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| 14. Jornada | 23.03.2021 | Danubio | - | Deportivo Maldonado | 2:2 | ||||
| 15. Jornada | 29.03.2021 | Rentistas | - | Danubio | 1:0 |
Uruguay
Italia 