| 2. Jornada | 07.08.2022 | Danubio | - | Deportivo Maldonado | 0:0 | ||||
| 3. Jornada | 13.08.2022 | Rentistas | - | Danubio | 0:1 |  |
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| 6. Jornada | 19.08.2022 | Danubio | - | Montevideo City Torque | 3:2 | ||||
| 5. Jornada | 28.08.2022 | Peñarol | - | Danubio | 1:1 | |
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| 4. Jornada | 03.09.2022 | Danubio | - | Liverpool | 1:1 | ||||
| 7. Jornada | 10.09.2022 | Montevideo Wanderers | - | Danubio | 0:3 | ||||
| 8. Jornada | 13.09.2022 | Danubio | - | Plaza Colonia | 1:1 | ||||
| 9. Jornada | 19.09.2022 | Boston River | - | Danubio | 0:1 | ||||
| 10. Jornada | 24.09.2022 | Danubio | - | River Plate | 3:0 |  |
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| 11. Jornada | 30.09.2022 | Cerro Largo | - | Danubio | 1:0 | ||||
| 12. Jornada | 08.10.2022 | Danubio | - | Fénix | 1:1 | ||||
| 13. Jornada | 13.10.2022 | Defensor Sporting | - | Danubio | 1:1 | ||||
| 14. Jornada | 16.10.2022 | Danubio | - | Albion | 3:0 | ||||
| 15. Jornada | 24.10.2022 | Nacional | - | Danubio | 2:0 |
Uruguay