| 1. Jornada | 17.01.2021 | Deportes Quindío | - | Valledupar FC | 1:2 | ||||
| 2. Jornada | 23.01.2021 | Valledupar FC | - | Orsomarso SC | 3:4 | ||||
| 3. Jornada | 31.01.2021 | Boca Juniors de Cali | - | Valledupar FC | 1:2 |  |
|||
| 4. Jornada | 09.02.2021 | Valledupar FC | - | Real Cartagena | 2:0 | ||||
| 5. Jornada | 12.02.2021 | Real Santander | - | Valledupar FC | 0:1 | ||||
| 6. Jornada | 15.02.2021 | Valledupar FC | - | Bogotá FC | 6:0 | ||||
| 7. Jornada | 23.02.2021 | Fortaleza FC | - | Valledupar FC | 3:2 | ||||
| 8. Jornada | 27.02.2021 | Valledupar FC | - | Leones FC | 0:1 | |
|||
| 9. Jornada | 04.03.2021 | Atlético Huila | - | Valledupar FC | 3:1 | ||||
| 10. Jornada | 07.03.2021 | Valledupar FC | - | Cortuluá | 1:2 | ||||
| 12. Jornada | 21.03.2021 | Valledupar FC | - | Barranquilla FC | 2:0 | ||||
| 15. Jornada | 09.04.2021 | Valledupar FC | - | Unión Magdalena | 1:2 | |
Colombia