| 6. Jornada | 12.09.2021 | FK AP Brera Strumica | - | Makedonija GP | 4:1 | ||||
| 9. Jornada | 02.10.2021 | FK Skopje | - | FK AP Brera Strumica | 0:0 | ||||
| 10. Jornada | 16.10.2021 | FK AP Brera Strumica | - | KF Shkëndija 79 | 2:1 |  |
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| 11. Jornada | 24.10.2021 | FK Borec | - | FK AP Brera Strumica | 1:2 | |
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| 12. Jornada | 30.10.2021 | FC Struga | - | FK AP Brera Strumica | 0:0 | ||||
| 13. Jornada | 06.11.2021 | FK Rabotnički | - | FK AP Brera Strumica | 0:3 | ||||
| 15. Jornada | 27.11.2021 | FK Renova | - | FK AP Brera Strumica | 1:2 | ||||
| 18. Jornada | 12.12.2021 | FK AP Brera Strumica | - | FK Pelister | 1:0 | |
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| 19. Jornada | 13.02.2022 | KF Shkupi | - | FK AP Brera Strumica | 2:1 |  |
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| 21. Jornada | 27.02.2022 | KF Shkëndija 79 | - | FK AP Brera Strumica | 0:0 | ||||
| 23. Jornada | 13.03.2022 | FK AP Brera Strumica | - | FC Struga | 1:0 | ||||
| 26. Jornada | 06.04.2022 | FK Borec | - | FK AP Brera Strumica | 1:1 | ||||
| 27. Jornada | 10.04.2022 | FK AP Brera Strumica | - | FK Pelister | 2:0 | ||||
| 28. Jornada | 17.04.2022 | FK Renova | - | FK AP Brera Strumica | 0:1 | |
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| 32. Jornada | 08.05.2022 | FK AP Brera Strumica | - | FK Rabotnički | 2:1 | ||||
| 33. Jornada | 15.05.2022 | KF Shkupi | - | FK AP Brera Strumica | 3:0 |
Macedonia del Norte