| 6. Jornada | 31.07.2022 | Santos Laguna [Sub 18] | - | Atlas Guadalajara [Sub 18] | 2:0 |  |
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| 1. Jornada | 03.08.2022 | Santos Laguna [Sub 18] | - | CF Monterrey [Sub 18] | 5:2 | ||||
| 11. Jornada | 28.08.2022 | Santos Laguna [Sub 18] | - | Atlético San Luis [Sub 18] | 0:1 | ||||
| 13. Jornada | 06.09.2022 | Santos Laguna [Sub 18] | - | Club Necaxa [Sub 18] | 3:0 | ||||
| 5. Jornada | 14.09.2022 | CF América [Sub 18] | - | Santos Laguna [Sub 18] | 5:1 | ||||
| 15. Jornada | 18.09.2022 | Santos Laguna [Sub 18] | - | FC Juárez [Sub 18] | 4:2 | ||||
| 4. Jornada | 22.09.2022 | Deportivo Toluca [Sub 18] | - | Santos Laguna [Sub 18] | 4:0 |
México