| 1. Jornada | 24.01.2022 | Alianza Petrolera | - | Deportivo Pereira | 2:1 | ||||
| 3. Jornada | 31.01.2022 | Alianza Petrolera | - | Envigado FC | 2:2 | ||||
| 4. Jornada | 02.02.2022 | Atlético Bucaramanga | - | Alianza Petrolera | 2:1 |  |
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| 5. Jornada | 07.02.2022 | Alianza Petrolera | - | Jaguares de Córdoba | 2:0 |  |
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| 8. Jornada | 20.02.2022 | Deportivo Cali | - | Alianza Petrolera | 1:1 | ||||
| 9. Jornada | 01.03.2022 | Deportivo Pasto | - | Alianza Petrolera | 1:1 | |
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| 13. Jornada | 28.03.2022 | Alianza Petrolera | - | Patriotas FC | 2:1 | ||||
| 14. Jornada | 03.04.2022 | Atlético Junior | - | Alianza Petrolera | 3:1 | ||||
| 15. Jornada | 11.04.2022 | Alianza Petrolera | - | Independiente Medellín | 1:1 | ||||
| 16. Jornada | 16.04.2022 | Santa Fe | - | Alianza Petrolera | 0:1 | ||||
| 17. Jornada | 25.04.2022 | Alianza Petrolera | - | Deportes Tolima | 0:2 | ||||
| 18. Jornada | 03.05.2022 | América de Cali | - | Alianza Petrolera | 0:1 | ||||
| 19. Jornada | 09.05.2022 | Alianza Petrolera | - | Once Caldas | 2:0 | ||||
| 20. Jornada | 15.05.2022 | Millonarios | - | Alianza Petrolera | 1:0 |
Colombia