| 1. Jornada | 09.07.2022 | Tigres FC | - | Fortaleza FC | 1:0 |  |
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| 2. Jornada | 17.07.2022 | Barranquilla FC | - | Tigres FC | 3:0 | ||||
| 4. Jornada | 30.07.2022 | Tigres FC | - | Leones FC | 1:1 | ||||
| 5. Jornada | 04.08.2022 | Boyacá Chicó | - | Tigres FC | 2:2 | ||||
| 6. Jornada | 09.08.2022 | Tigres FC | - | Deportes Quindío | 2:0 | |
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| 7. Jornada | 14.08.2022 | Valledupar FC | - | Tigres FC | 1:1 | ||||
| 3. Jornada | 18.08.2022 | Atlético FC | - | Tigres FC | 1:0 | ||||
| 8. Jornada | 24.08.2022 | Tigres FC | - | Atlético Huila | 1:2 | ||||
| 9. Jornada | 29.08.2022 | Bogotá FC | - | Tigres FC | 0:1 | ||||
| 10. Jornada | 03.09.2022 | Tigres FC | - | Real Santander | 2:2 | ||||
| 11. Jornada | 07.09.2022 | Real Cartagena | - | Tigres FC | 0:1 | ||||
| 12. Jornada | 12.09.2022 | Tigres FC | - | Orsomarso SC | 1:0 | ||||
| 13. Jornada | 18.09.2022 | Tigres FC | - | Boca Juniors de Cali | 3:2 | ||||
| 14. Jornada | 24.09.2022 | Llaneros FC | - | Tigres FC | 2:0 | ||||
| 15. Jornada | 01.10.2022 | Tigres FC | - | Bogotá FC | 2:1 | |
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| 16. Jornada | 08.10.2022 | Cúcuta Deportivo | - | Tigres FC | 2:1 |
Colombia