| 1. Jornada | 14.03.2022 | FC Botoşani | - | Gaz Metan Mediaş | 5:0 |  |
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| 2. Jornada | 18.03.2022 | FC Botoşani | - | UTA Arad | 1:0 | ||||
| 3. Jornada | 02.04.2022 | Rapid Bucureşti | - | FC Botoşani | 3:0 | ||||
| 4. Jornada | 10.04.2022 | FC Botoşani | - | Sepsi OSK | 0:1 | ||||
| 5. Jornada | 15.04.2022 | Chindia Târgoviște | - | FC Botoşani | 1:2 | ||||
| 7. Jornada | 02.05.2022 | CS Mioveni | - | FC Botoşani | 0:2 | ||||
| 8. Jornada | 06.05.2022 | FC Botoşani | - | Dinamo Bucureşti | 2:3 | ||||
| 9. Jornada | 16.05.2022 | Academica Clinceni | - | FC Botoşani | 0:4 |
Rumania