| 3. Jornada | 26.04.2021 | Santiago Morning | - | Santa Cruz | 1:3 | ||||
| 21. Jornada | 24.09.2021 | Coquimbo Unido | - | Santa Cruz | 0:0 |  |
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| 22. Jornada | 28.09.2021 | Santa Cruz | - | Unión San Felipe | 0:1 | ||||
| 24. Jornada | 08.10.2021 | Santa Cruz | - | Deportes Copiapó | 1:2 | |
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| 25. Jornada | 12.10.2021 | San Luis | - | Santa Cruz | 0:0 |
Chile