| 1. Jornada | 04.04.2021 | Cobreloa | - | Barnechea | 1:2 | ||||
| 2. Jornada | 18.04.2021 | San Marcos | - | Cobreloa | 0:0 | ||||
| 3. Jornada | 26.04.2021 | Cobreloa | - | Universidad de Concepción | 2:4 | ||||
| 4. Jornada | 04.05.2021 | Cobreloa | - | Coquimbo Unido | 1:1 | ||||
| 5. Jornada | 10.05.2021 | Unión San Felipe | - | Cobreloa | 0:0 | ||||
| 6. Jornada | 18.05.2021 | Cobreloa | - | Santiago Morning | 2:2 | ||||
| 9. Jornada | 07.06.2021 | CD Magallanes | - | Cobreloa | 2:2 |  |
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| 18. Jornada | 02.09.2021 | Universidad de Concepción | - | Cobreloa | 0:0 | ||||
| 20. Jornada | 16.09.2021 | Cobreloa | - | Unión San Felipe | 2:1 | ||||
| 21. Jornada | 22.09.2021 | Santiago Morning | - | Cobreloa | 2:1 |  |
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| 22. Jornada | 26.09.2021 | Cobreloa | - | Fernández Vial | 1:2 | ||||
| 23. Jornada | 02.10.2021 | San Luis | - | Cobreloa | 1:0 | |
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| 24. Jornada | 06.10.2021 | Cobreloa | - | CD Magallanes | 2:1 | ||||
| 25. Jornada | 13.10.2021 | Deportes Iquique | - | Cobreloa | 1:0 | ||||
| 7. Jornada | 21.10.2021 | Fernández Vial | - | Cobreloa | 3:2 | ||||
| 27. Jornada | 28.10.2021 | Puerto Montt | - | Cobreloa | 0:0 |
Uruguay