| 1. Jornada | 03.02.2025 | Leones FC | - | Boca Juniors de Cali | 1:1 |  |
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| 2. Jornada | 10.02.2025 | Orsomarso SC | - | Leones FC | 2:3 | |
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| 3. Jornada | 18.02.2025 | Leones FC | - | Real Cartagena | 1:2 | |
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| 4. Jornada | 24.02.2025 | Barranquilla FC | - | Leones FC | 2:3 | ||||
| 5. Jornada | 03.03.2025 | Tigres FC | - | Leones FC | 1:1 | |
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| 6. Jornada | 12.03.2025 | Leones FC | - | Internacional de Palmira | 1:2 | ||||
| 7. Jornada | 17.03.2025 | Real Santander | - | Leones FC | 1:0 | ||||
| 10. Jornada | 06.04.2025 | Leones FC | - | Deportes Quindío | 4:1 | |
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| 12. Jornada | 21.04.2025 | Atlético Huila | - | Leones FC | 2:0 | |
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| 13. Jornada | 26.04.2025 | Leones FC | - | Cúcuta Deportivo | 0:1 | ||||
| 14. Jornada | 05.05.2025 | Leones FC | - | Jaguares de Córdoba | 1:3 | |
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| 15. Jornada | 10.05.2025 | Atlético FC | - | Leones FC | 0:0 | ||||
| 16. Jornada | 17.05.2025 | Leones FC | - | Bogotá FC | 3:0 |
Colombia