| 1. Jornada | 10.01.2021 | Atlas Guadalajara | - | CF Monterrey | 0:2 | ||||
| 2. Jornada | 17.01.2021 | CF Monterrey | - | CF América | 1:0 | ||||
| 4. Jornada | 03.02.2021 | Puebla FC | - | CF Monterrey | 0:0 | ||||
| 5. Jornada | 07.02.2021 | CF Monterrey | - | Pumas UNAM | 1:0 | ||||
| 6. Jornada | 15.02.2021 | Santos Laguna | - | CF Monterrey | 1:0 | ||||
| 7. Jornada | 20.02.2021 | Club Necaxa | - | CF Monterrey | 1:1 | ||||
| 8. Jornada | 01.03.2021 | CF Monterrey | - | Club Tijuana | 1:1 |  |
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| 9. Jornada | 04.03.2021 | FC Juárez | - | CF Monterrey | 1:6 | |
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| 10. Jornada | 07.03.2021 | CF Monterrey | - | Gallos Blancos | 2:1 | ||||
| 3. Jornada | 11.03.2021 | CF Monterrey | - | Club León | 1:1 | ||||
| 11. Jornada | 14.03.2021 | Cruz Azul | - | CF Monterrey | 1:0 | ||||
| 13. Jornada | 04.04.2021 | CF Monterrey | - | Atlético San Luis | 2:0 | ||||
| 14. Jornada | 11.04.2021 | Deportivo Toluca | - | CF Monterrey | 1:2 |  |
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| 15. Jornada | 19.04.2021 | CF Monterrey | - | CF Pachuca | 0:1 | |
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| 12. Jornada | 22.04.2021 | CF Monterrey | - | Deportivo Guadalajara | 1:2 | ||||
| 16. Jornada | 25.04.2021 | UANL Tigres | - | CF Monterrey | 2:1 |  |
Chile