| 1. Jornada | 09.08.2021 | Honduras Progreso | - | Marathón | 1:2 |  |
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| 2. Jornada | 11.08.2021 | Marathón | - | Lobos UPNFM | 5:1 | ||||
| 6. Jornada | 29.08.2021 | Marathón | - | Real España | 0:1 | ||||
| 16. Jornada | 28.10.2021 | Olimpia | - | Marathón | 1:0 | |
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| 17. Jornada | 30.10.2021 | Marathón | - | Victoria | 0:0 | ||||
| 18. Jornada | 10.11.2021 | Real Sociedad | - | Marathón | 0:3 |
Honduras