| 5. Jornada | 21.08.2021 | Santos Laguna [Sub 16] | - | Atlético San Luis [Sub 16] | 2:0 | ||||
| 7. Jornada | 04.09.2021 | Santos Laguna [Sub 16] | - | Club León [Sub 16] | 1:0 | ||||
| 11. Jornada | 02.10.2021 | Atlético San Luis [Sub 16] | - | Santos Laguna [Sub 16] | 0:3 | ||||
| 13. Jornada | 16.10.2021 | Santos Laguna [Sub 16] | - | CF Monterrey [Sub 16] | 1:1 | ||||
| 16. Jornada | 06.11.2021 | UANL Tigres [Sub 16] | - | Santos Laguna [Sub 16] | 4:0 |
México