| 8. Jornada | 18.02.2021 | Fénix | - | Danubio | 1:1 | ||||
| 9. Jornada | 22.02.2021 | Danubio | - | CA Cerro | 2:1 | ||||
| 10. Jornada | 28.02.2021 | Defensor Sporting | - | Danubio | 1:1 |  |
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| 11. Jornada | 07.03.2021 | Danubio | - | Liverpool | 0:1 |  |
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| 13. Jornada | 19.03.2021 | Boston River | - | Danubio | 1:5 | ||||
| 14. Jornada | 23.03.2021 | Danubio | - | Deportivo Maldonado | 2:2 | |
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| 15. Jornada | 29.03.2021 | Rentistas | - | Danubio | 1:0 | |
Uruguay