| 1. Jornada | 24.07.2010 | Hajduk Split | - | NK Istra 1961 | 6:1 |  |
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| 2. Jornada | 31.07.2010 | NK Istra 1961 | - | NK Zagreb | 0:2 | ||||
| 3. Jornada | 07.08.2010 | Lokomotiva Zagreb | - | NK Istra 1961 | 1:0 | ||||
| 4. Jornada | 13.08.2010 | Hrvatski Dragovoljac | - | NK Istra 1961 | 1:1 | ||||
| 5. Jornada | 21.08.2010 | NK Istra 1961 | - | NK Osijek | 1:2 | |
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| 6. Jornada | 28.08.2010 | HNK Šibenik | - | NK Istra 1961 | 2:2 | ||||
| 7. Jornada | 11.09.2010 | NK Istra 1961 | - | NK Inter Zaprešić | 0:1 | |
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| 9. Jornada | 25.09.2010 | NK Istra 1961 | - | RNK Split | 0:1 | |
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| 11. Jornada | 16.10.2010 | NK Istra 1961 | - | HNK Rijeka | 0:0 | ||||
| 12. Jornada | 23.10.2010 | NK Varaždin | - | NK Istra 1961 | 2:1 | ||||
| 13. Jornada | 30.10.2010 | NK Istra 1961 | - | NK Karlovac | 1:0 | ||||
| 14. Jornada | 06.11.2010 | Slaven Belupo | - | NK Istra 1961 | 2:1 | |
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| 15. Jornada | 13.11.2010 | NK Istra 1961 | - | HNK Cibalia | 1:0 |  |
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| 17. Jornada | 27.11.2010 | NK Zagreb | - | NK Istra 1961 | 0:1 | |
Croacia