| 1. Jornada | 08.08.2021 | Real Sociedad | - | Olimpia | 0:3 | ||||
| 2. Jornada | 12.08.2021 | Real Sociedad | - | Vida | 3:3 | ||||
| 3. Jornada | 15.08.2021 | Victoria | - | Real Sociedad | 0:2 |  |
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| 9. Jornada | 15.09.2021 | Lobos UPNFM | - | Real Sociedad | 2:0 | |
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| 12. Jornada | 03.10.2021 | Vida | - | Real Sociedad | 2:1 | ||||
| 13. Jornada | 10.10.2021 | Olimpia | - | Real Sociedad | 4:0 | ||||
| 17. Jornada | 01.11.2021 | Honduras Progreso | - | Real Sociedad | 2:1 | |
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| 18. Jornada | 10.11.2021 | Real Sociedad | - | Marathón | 0:3 |
Honduras