| 1. Jornada | 07.11.2021 | Anagennisi Karditsa | - | Thesprotos | 1:0 | ||||
| 5. Jornada | 28.11.2021 | Anagennisi Karditsa | - | Olympiacos Volou | 4:0 | ||||
| 6. Jornada | 05.12.2021 | PAOK Saloniki II | - | Anagennisi Karditsa | 2:1 | ||||
| 8. Jornada | 15.12.2021 | AE Lárissa | - | Anagennisi Karditsa | 0:0 | ||||
| 10. Jornada | 29.12.2021 | Olympiakos Piraeus II | - | Anagennisi Karditsa | 0:1 | ||||
| 17. Jornada | 06.02.2022 | Xanthi FC | - | Anagennisi Karditsa | 5:2 | ||||
| 30. Jornada | 10.04.2022 | Veria FC | - | Anagennisi Karditsa | 2:0 |  |
|||
| 31. Jornada | 13.04.2022 | Anagennisi Karditsa | - | Apollon Pontou | 2:1 | ||||
| 27. Jornada | 23.04.2022 | Anagennisi Karditsa | - | Olympiakos Piraeus II | 0:1 | ||||
| 33. Jornada | 27.04.2022 | Pierikos Katerini | - | Anagennisi Karditsa | 2:2 |
Grecia