| 1. Jornada | 28.08.2021 | Twente/Heracles [Sub 21] | - | Almere City FC [Sub 21] | 1:2 |  |
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| 5. Jornada | 02.10.2021 | Twente/Heracles [Sub 21] | - | ADO Den Haag [Sub 21] | 0:0 | ||||
| 6. Jornada | 16.10.2021 | Twente/Heracles [Sub 21] | - | FC Groningen [Sub 21] | 1:2 | ||||
| 7. Jornada | 23.10.2021 | sc Heerenveen [Sub 21] | - | Twente/Heracles [Sub 21] | 0:3 | ||||
| 8. Jornada | 30.10.2021 | ADO Den Haag [Sub 21] | - | Twente/Heracles [Sub 21] | 3:1 | ||||
| 10. Jornada | 20.11.2021 | NAC Breda [Sub 21] | - | Twente/Heracles [Sub 21] | 3:1 | ||||
| 11. Jornada | 04.12.2021 | Twente/Heracles [Sub 21] | - | NEC Nijmegen [Sub 21] | 1:1 | ||||
| 13. Jornada | 26.02.2022 | Twente/Heracles [Sub 21] | - | sc Heerenveen [Sub 21] | 1:1 |
Bulgaria