| 1. Jornada | 27.02.2022 | Inter Miami CF | - | Chicago Fire | 0:0 | ||||
| 2. Jornada | 06.03.2022 | Chicago Fire | - | Orlando City | 0:0 | ||||
| 2. Jornada | 13.03.2022 | D.C. United | - | Chicago Fire | 0:2 |  |
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| 2. Jornada | 19.03.2022 | Chicago Fire | - | Sporting Kansas City | 3:1 | ||||
| 3. Jornada | 02.04.2022 | Chicago Fire | - | FC Dallas | 0:0 | ||||
| 3. Jornada | 09.04.2022 | Orlando City | - | Chicago Fire | 1:0 | ||||
| 3. Jornada | 17.04.2022 | Chicago Fire | - | Los Angeles Galaxy | 0:0 | ||||
| 3. Jornada | 23.04.2022 | Minnesota United FC | - | Chicago Fire | 3:0 | ||||
| 4. Jornada | 08.05.2022 | Atlanta United FC | - | Chicago Fire | 4:1 | ||||
| 5. Jornada | 19.06.2022 | Chicago Fire | - | D.C. United | 1:0 | ||||
| 5. Jornada | 26.06.2022 | Houston Dynamo | - | Chicago Fire | 2:0 | ||||
| 6. Jornada | 14.07.2022 | Chicago Fire | - | Toronto FC | 2:0 | ||||
| 8. Jornada | 18.09.2022 | Chicago Fire | - | Charlotte FC | 2:3 | ||||
| 9. Jornada | 02.10.2022 | FC Cincinnati | - | Chicago Fire | 2:3 | ||||
| 9. Jornada | 09.10.2022 | Chicago Fire | - | New England Revolution | 1:1 |
Bulgaria