| 2. Jornada | 13.09.2021 | APOEL Nikosia | - | Olympiacos Nikosia | 0:1 | ||||
| 3. Jornada | 18.09.2021 | Olympiacos Nikosia | - | AEL Limassol | 1:1 | ||||
| 5. Jornada | 03.10.2021 | Olympiacos Nikosia | - | Omonia Nikosia | 1:0 |  |
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| 8. Jornada | 31.10.2021 | Olympiacos Nikosia | - | Apollon Limassol | 0:2 | |
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| 9. Jornada | 05.11.2021 | PAEEK | - | Olympiacos Nikosia | 0:0 | ||||
| 10. Jornada | 20.11.2021 | Olympiacos Nikosia | - | Anorthosis Famagusta | 3:2 | ||||
| 11. Jornada | 26.11.2021 | Ethnikos Achna | - | Olympiacos Nikosia | 1:0 | ||||
| 12. Jornada | 03.12.2021 | Aris Limassol | - | Olympiacos Nikosia | 1:0 | ||||
| 17. Jornada | 15.01.2022 | Olympiacos Nikosia | - | Paphos FC | 1:2 |  |
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| 18. Jornada | 23.01.2022 | Doxa Katokopias | - | Olympiacos Nikosia | 0:0 | ||||
| 19. Jornada | 30.01.2022 | Apollon Limassol | - | Olympiacos Nikosia | 2:1 | |
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| 15. Jornada | 09.02.2022 | Olympiacos Nikosia | - | AEK Larnaca | 0:0 | ||||
| 20. Jornada | 22.02.2022 | Olympiacos Nikosia | - | PAEEK | 1:0 |
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