| 1. Jornada | 17.01.2021 | Apollon Lárissa | - | Xanthi FC | 1:1 | ||||
| 4. Jornada | 27.01.2021 | Levadiakos | - | Xanthi FC | 1:1 | ||||
| 5. Jornada | 30.01.2021 | Xanthi FC | - | PAE Chania | 0:0 | ||||
| 6. Jornada | 06.02.2021 | Ergotelis | - | Xanthi FC | 2:1 | ||||
| 7. Jornada | 10.02.2021 | AE Karaiskakis | - | Xanthi FC | 0:1 | ||||
| 8. Jornada | 13.02.2021 | Xanthi FC | - | AO Trikala | 1:0 |  |
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| 9. Jornada | 17.02.2021 | Diagoras FC | - | Xanthi FC | 1:0 | |
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| 10. Jornada | 21.02.2021 | Xanthi FC | - | OFI Ierapetra | 2:1 | ||||
| 3. Jornada | 10.03.2021 | Xanthi FC | - | Doxa Dramas FC | 1:0 | ||||
| 14. Jornada | 14.03.2021 | Doxa Dramas FC | - | Xanthi FC | 0:3 | ||||
| 15. Jornada | 17.03.2021 | Xanthi FC | - | Levadiakos | 1:0 | ||||
| 16. Jornada | 21.03.2021 | PAE Chania | - | Xanthi FC | 0:0 | |
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| 17. Jornada | 27.03.2021 | Xanthi FC | - | Ergotelis | 1:0 | ||||
| 18. Jornada | 03.04.2021 | Xanthi FC | - | AE Karaiskakis | 1:1 | ||||
| 19. Jornada | 07.04.2021 | AO Trikala | - | Xanthi FC | 0:0 | ||||
| 22. Jornada | 21.04.2021 | Xanthi FC | - | Panachaiki GE | 4:0 |
Grecia