| 1. Jornada | 17.01.2021 | Apollon Lárissa | - | Xanthi FC | 1:1 | ||||
| 2. Jornada | 20.01.2021 | Xanthi FC | - | Ionikos Nikea | 1:0 | ||||
| 4. Jornada | 27.01.2021 | Levadiakos | - | Xanthi FC | 1:1 | ||||
| 5. Jornada | 30.01.2021 | Xanthi FC | - | PAE Chania | 0:0 | ||||
| 6. Jornada | 06.02.2021 | Ergotelis | - | Xanthi FC | 2:1 |  |
|||
| 15. Jornada | 17.03.2021 | Xanthi FC | - | Levadiakos | 1:0 | ||||
| 16. Jornada | 21.03.2021 | PAE Chania | - | Xanthi FC | 0:0 | ||||
| 17. Jornada | 27.03.2021 | Xanthi FC | - | Ergotelis | 1:0 | ||||
| 18. Jornada | 03.04.2021 | Xanthi FC | - | AE Karaiskakis | 1:1 | ||||
| 19. Jornada | 07.04.2021 | AO Trikala | - | Xanthi FC | 0:0 | ||||
| 20. Jornada | 11.04.2021 | Xanthi FC | - | Diagoras FC | 2:0 | ||||
| 21. Jornada | 17.04.2021 | OFI Ierapetra | - | Xanthi FC | 1:2 | ||||
| 22. Jornada | 21.04.2021 | Xanthi FC | - | Panachaiki GE | 4:0 |
Grecia