| 1. Jornada | 20.08.2021 | Mamelodi Sundowns | - | AmaZulu FC | 1:0 | ||||
| 2. Jornada | 24.08.2021 | Chippa United | - | Mamelodi Sundowns | 0:0 | ||||
| 3. Jornada | 12.09.2021 | Mamelodi Sundowns | - | Kaizer Chiefs | 2:0 | ||||
| 7. Jornada | 20.10.2021 | Golden Arrows | - | Mamelodi Sundowns | 0:1 | ||||
| 10. Jornada | 07.11.2021 | Marumo Gallants | - | Mamelodi Sundowns | 0:4 | ||||
| 11. Jornada | 20.11.2021 | Cape Town City FC | - | Mamelodi Sundowns | 0:0 | ||||
| 13. Jornada | 04.12.2021 | Stellenbosch FC | - | Mamelodi Sundowns | 1:1 | ||||
| 14. Jornada | 08.12.2021 | Mamelodi Sundowns | - | Royal AM | 3:2 | ||||
| 15. Jornada | 11.12.2021 | SuperSport United | - | Mamelodi Sundowns | 0:1 | ||||
| 22. Jornada | 14.12.2021 | Mamelodi Sundowns | - | Baroka FC | 2:1 | ||||
| 16. Jornada | 17.12.2021 | Mamelodi Sundowns | - | Orlando Pirates | 4:1 | ||||
| 17. Jornada | 20.12.2021 | AmaZulu FC | - | Mamelodi Sundowns | 1:0 | ||||
| 23. Jornada | 23.12.2021 | Mamelodi Sundowns | - | Marumo Gallants | 1:1 |  |
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| 18. Jornada | 07.02.2022 | Mamelodi Sundowns | - | Chippa United | 2:0 | ||||
| 20. Jornada | 02.03.2022 | TS Galaxy | - | Mamelodi Sundowns | 0:3 | ||||
| 21. Jornada | 05.03.2022 | Maritzburg United | - | Mamelodi Sundowns | 2:1 |
Sudáfrica