| 4. Jornada | 15.08.2021 | Gante | - | KV Mechelen | 2:0 | ||||
| 5. Jornada | 22.08.2021 | KV Mechelen | - | Union Saint-Gilloise | 3:1 | ||||
| 6. Jornada | 27.08.2021 | KV Kortrijk | - | KV Mechelen | 2:2 | ||||
| 17. Jornada | 05.12.2021 | KV Mechelen | - | KRC Genk | 1:1 | ||||
| 18. Jornada | 12.12.2021 | Union Saint-Gilloise | - | KV Mechelen | 2:0 | ||||
| 19. Jornada | 15.12.2021 | KV Mechelen | - | Gante | 4:3 | ||||
| 20. Jornada | 18.12.2021 | SV Zulte Waregem | - | KV Mechelen | 3:2 | ||||
| 21. Jornada | 27.12.2021 | KV Mechelen | - | RFC Seraing | 2:0 | ||||
| 23. Jornada | 23.01.2022 | KV Mechelen | - | RSC Anderlecht | 0:1 | ||||
| 25. Jornada | 30.01.2022 | Standard Liège | - | KV Mechelen | 1:2 |  |
|||
| 26. Jornada | 06.02.2022 | KV Mechelen | - | K Beerschot VA | 3:2 | ||||
| 27. Jornada | 12.02.2022 | KV Mechelen | - | KV Oostende | 3:0 | ||||
| 24. Jornada | 16.02.2022 | KRC Genk | - | KV Mechelen | 4:1 |  |
|||
| 31. Jornada | 12.03.2022 | KV Mechelen | - | Sporting Charleroi | 2:2 | ||||
| 33. Jornada | 02.04.2022 | KV Mechelen | - | KV Kortrijk | 3:2 |
Francia