| 1. Jornada | 24.07.2022 | KV Mechelen | - | Royal Antwerp FC | 0:2 | ||||
| 2. Jornada | 30.07.2022 | KV Oostende | - | KV Mechelen | 2:1 |  |
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| 3. Jornada | 06.08.2022 | KV Mechelen | - | Union Saint-Gilloise | 3:0 | ||||
| 4. Jornada | 13.08.2022 | Cercle Brugge | - | KV Mechelen | 0:0 | ||||
| 5. Jornada | 21.08.2022 | KV Mechelen | - | KVC Westerlo | 5:4 | ||||
| 6. Jornada | 27.08.2022 | Sint-Truidense VV | - | KV Mechelen | 3:1 | ||||
| 7. Jornada | 03.09.2022 | KV Mechelen | - | RFC Seraing | 2:3 | |
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| 8. Jornada | 10.09.2022 | KV Kortrijk | - | KV Mechelen | 1:4 | ||||
| 9. Jornada | 17.09.2022 | KV Mechelen | - | Oud-Heverlee Leuven | 0:0 | ||||
| 10. Jornada | 01.10.2022 | Club Brugge KV | - | KV Mechelen | 3:0 | ||||
| 11. Jornada | 09.10.2022 | KV Mechelen | - | RSC Anderlecht | 1:3 | ||||
| 12. Jornada | 16.10.2022 | Gante | - | KV Mechelen | 3:0 | ||||
| 13. Jornada | 19.10.2022 | KV Mechelen | - | Standard Liège | 2:0 | ||||
| 14. Jornada | 22.10.2022 | KV Mechelen | - | KAS Eupen | 2:1 | ||||
| 15. Jornada | 28.10.2022 | KRC Genk | - | KV Mechelen | 3:1 |
Francia