| 23. Jornada | 21.01.2022 | Helmond Sport | - | TOP Oss | 1:3 | ||||
| 25. Jornada | 04.02.2022 | Jong PSV | - | Helmond Sport | 2:0 | ||||
| 24. Jornada | 07.02.2022 | FC Utrecht (J) | - | Helmond Sport | 3:2 |  |
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| 26. Jornada | 11.02.2022 | Helmond Sport | - | Telstar | 2:2 | ||||
| 28. Jornada | 25.02.2022 | FC Volendam | - | Helmond Sport | 4:1 | ||||
| 22. Jornada | 01.03.2022 | FC Emmen | - | Helmond Sport | 1:2 | ||||
| 29. Jornada | 04.03.2022 | Helmond Sport | - | FC Eindhoven | 1:2 | ||||
| 30. Jornada | 11.03.2022 | Almere City FC | - | Helmond Sport | 3:0 | ||||
| 27. Jornada | 14.03.2022 | Helmond Sport | - | VVV-Venlo | 0:3 | ||||
| 31. Jornada | 18.03.2022 | Helmond Sport | - | NAC Breda | 4:0 | |
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| 32. Jornada | 26.03.2022 | SBV Excelsior | - | Helmond Sport | 3:0 | ||||
| 33. Jornada | 01.04.2022 | Helmond Sport | - | MVV | 1:2 | ||||
| 34. Jornada | 08.04.2022 | ADO Den Haag | - | Helmond Sport | 2:1 | ||||
| 35. Jornada | 15.04.2022 | Roda JC Kerkrade | - | Helmond Sport | 5:3 | |
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| 36. Jornada | 22.04.2022 | Helmond Sport | - | De Graafschap | 0:4 | ||||
| 37. Jornada | 29.04.2022 | AZ Alkmaar (J) | - | Helmond Sport | 0:1 | ||||
| 38. Jornada | 06.05.2022 | Helmond Sport | - | FC Den Bosch | 1:1 |
Países Bajos