| 1. Jornada | 23.08.2021 | Apollon Limassol | - | Ethnikos Achna | 4:2 |  |
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| 2. Jornada | 11.09.2021 | Ethnikos Achna | - | PAEEK | 1:3 | ||||
| 3. Jornada | 20.09.2021 | Anorthosis Famagusta | - | Ethnikos Achna | 2:1 | ||||
| 5. Jornada | 02.10.2021 | Ethnikos Achna | - | Aris Limassol | 0:3 | ||||
| 6. Jornada | 18.10.2021 | APOEL Nikosia | - | Ethnikos Achna | 2:1 | ||||
| 8. Jornada | 31.10.2021 | AEK Larnaca | - | Ethnikos Achna | 1:0 | ||||
| 9. Jornada | 07.11.2021 | Ethnikos Achna | - | Omonia Nikosia | 0:2 | |
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| 10. Jornada | 20.11.2021 | Paphos FC | - | Ethnikos Achna | 3:0 | |
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| 16. Jornada | 08.01.2022 | Aris Limassol | - | Ethnikos Achna | 2:1 | ||||
| 18. Jornada | 22.01.2022 | AEL Limassol | - | Ethnikos Achna | 1:0 | ||||
| 19. Jornada | 29.01.2022 | Ethnikos Achna | - | AEK Larnaca | 0:0 | ||||
| 20. Jornada | 07.02.2022 | Omonia Nikosia | - | Ethnikos Achna | 0:2 | |
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| 21. Jornada | 13.02.2022 | Ethnikos Achna | - | Paphos FC | 0:1 | ||||
| 22. Jornada | 27.02.2022 | Olympiacos Nikosia | - | Ethnikos Achna | 0:0 |
Chipre