| 1. Jornada | 09.08.2021 | FC Utrecht (J) | - | MVV | 0:1 | ||||
| 2. Jornada | 13.08.2021 | MVV | - | De Graafschap | 1:3 | ||||
| 3. Jornada | 20.08.2021 | MVV | - | Helmond Sport | 3:2 | ||||
| 13. Jornada | 29.11.2021 | MVV | - | Roda JC Kerkrade | 1:1 | ||||
| 20. Jornada | 17.12.2021 | MVV | - | FC Emmen | 0:1 | ||||
| 21. Jornada | 07.01.2022 | Roda JC Kerkrade | - | MVV | 1:0 |  |
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| 22. Jornada | 14.01.2022 | Telstar | - | MVV | 2:1 | ||||
| 23. Jornada | 21.01.2022 | MVV | - | FC Volendam | 0:1 | ||||
| 25. Jornada | 04.02.2022 | MVV | - | VVV-Venlo | 0:5 | ||||
| 26. Jornada | 11.02.2022 | ADO Den Haag | - | MVV | 2:3 | ||||
| 30. Jornada | 11.03.2022 | FC Den Bosch | - | MVV | 3:1 | ||||
| 27. Jornada | 14.03.2022 | MVV | - | AZ Alkmaar (J) | 2:3 | ||||
| 31. Jornada | 18.03.2022 | De Graafschap | - | MVV | 1:3 | ||||
| 32. Jornada | 27.03.2022 | MVV | - | Almere City FC | 0:3 | ||||
| 33. Jornada | 01.04.2022 | Helmond Sport | - | MVV | 1:2 | ||||
| 35. Jornada | 15.04.2022 | MVV | - | SBV Excelsior | 1:1 | ||||
| 37. Jornada | 29.04.2022 | MVV | - | Jong Ajax | 1:0 | ||||
| 38. Jornada | 06.05.2022 | TOP Oss | - | MVV | 0:1 |
Países Bajos