| 4. Jornada | 13.08.2021 | AS Trenčín | - | MFK Ružomberok | 1:1 | ||||
| 5. Jornada | 21.08.2021 | MFK Ružomberok | - | Spartak Trnava | 0:0 |  |
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| 6. Jornada | 28.08.2021 | MFK Ružomberok | - | MFK Zemplín Michalovce | 0:0 | ||||
| 8. Jornada | 18.09.2021 | MFK Ružomberok | - | FC DAC 1904 | 1:2 | ||||
| 3. Jornada | 22.09.2021 | MFK Ružomberok | - | Slovan Bratislava | 1:0 | ||||
| 9. Jornada | 25.09.2021 | MŠK Žilina | - | MFK Ružomberok | 0:2 | ||||
| 11. Jornada | 16.10.2021 | FK Pohronie | - | MFK Ružomberok | 2:2 |  |
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| 12. Jornada | 23.10.2021 | FK Senica | - | MFK Ružomberok | 0:2 | |
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| 14. Jornada | 07.11.2021 | Slovan Bratislava | - | MFK Ružomberok | 1:0 |
Macedonia del Norte