| 1. Jornada | 25.07.2021 | Spartak Trnava | - | FK Pohronie | 2:0 | ||||
| 5. Jornada | 20.08.2021 | Zlaté Moravce | - | FK Pohronie | 1:0 | ||||
| 6. Jornada | 27.08.2021 | FK Pohronie | - | FC DAC 1904 | 0:3 | ||||
| 7. Jornada | 11.09.2021 | FK Senica | - | FK Pohronie | 1:0 | ||||
| 8. Jornada | 18.09.2021 | Tatran Liptovský Mikuláš | - | FK Pohronie | 5:1 | ||||
| 9. Jornada | 24.09.2021 | FK Pohronie | - | AS Trenčín | 2:2 |  |
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| 10. Jornada | 03.10.2021 | Slovan Bratislava | - | FK Pohronie | 5:1 | ||||
| 11. Jornada | 16.10.2021 | FK Pohronie | - | MFK Ružomberok | 2:2 | ||||
| 12. Jornada | 23.10.2021 | FK Pohronie | - | Spartak Trnava | 0:2 | ||||
| 13. Jornada | 30.10.2021 | MFK Zemplín Michalovce | - | FK Pohronie | 0:2 | ||||
| 14. Jornada | 06.11.2021 | FK Pohronie | - | MŠK Žilina | 1:2 | ||||
| 15. Jornada | 20.11.2021 | ŠKF Sereď | - | FK Pohronie | 3:1 | ||||
| 16. Jornada | 27.11.2021 | FK Pohronie | - | Zlaté Moravce | 0:2 | ||||
| 17. Jornada | 04.12.2021 | FC DAC 1904 | - | FK Pohronie | 2:0 | ||||
| 18. Jornada | 11.12.2021 | FK Pohronie | - | FK Senica | 0:1 | ||||
| 19. Jornada | 18.12.2021 | FK Pohronie | - | Tatran Liptovský Mikuláš | 2:2 |
Eslovaquia