| 4. Jornada | 26.08.2022 | Telstar | - | Helmond Sport | 2:1 |  |
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| 5. Jornada | 02.09.2022 | Helmond Sport | - | Almere City FC | 3:0 | ||||
| 6. Jornada | 09.09.2022 | FC Utrecht (J) | - | Helmond Sport | 2:0 | ||||
| 7. Jornada | 16.09.2022 | Helmond Sport | - | FC Dordrecht | 2:1 | |
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| 8. Jornada | 23.09.2022 | Heracles Almelo | - | Helmond Sport | 2:0 | |
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| 9. Jornada | 30.09.2022 | Helmond Sport | - | TOP Oss | 1:2 | ||||
| 10. Jornada | 07.10.2022 | Jong Ajax | - | Helmond Sport | 0:1 | ||||
| 11. Jornada | 14.10.2022 | Helmond Sport | - | Willem II | 1:3 | ||||
| 12. Jornada | 24.10.2022 | Jong PSV | - | Helmond Sport | 6:0 | ||||
| 13. Jornada | 28.10.2022 | Helmond Sport | - | ADO Den Haag | 2:1 | ||||
| 14. Jornada | 04.11.2022 | MVV | - | Helmond Sport | 4:0 | |
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| 15. Jornada | 12.11.2022 | Roda JC Kerkrade | - | Helmond Sport | 0:1 | |
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| 17. Jornada | 12.12.2022 | PEC Zwolle | - | Helmond Sport | 1:0 |
Países Bajos