| 1. Jornada | 24.07.2021 | MFK Ružomberok | - | FK Senica | 0:0 |  |
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| 2. Jornada | 01.08.2021 | FK Senica | - | Spartak Trnava | 2:1 | ||||
| 3. Jornada | 06.08.2021 | Zlaté Moravce | - | FK Senica | 1:1 |  |
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| 5. Jornada | 22.08.2021 | MŠK Žilina | - | FK Senica | 3:0 | ||||
| 6. Jornada | 28.08.2021 | Tatran Liptovský Mikuláš | - | FK Senica | 1:2 | ||||
| 7. Jornada | 11.09.2021 | FK Senica | - | FK Pohronie | 1:0 | ||||
| 8. Jornada | 18.09.2021 | AS Trenčín | - | FK Senica | 3:3 | ||||
| 10. Jornada | 02.10.2021 | ŠKF Sereď | - | FK Senica | 2:1 | ||||
| 11. Jornada | 16.10.2021 | FK Senica | - | MFK Zemplín Michalovce | 1:1 | ||||
| 13. Jornada | 29.10.2021 | Spartak Trnava | - | FK Senica | 2:1 |
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