| 11. Jornada | 02.06.2021 | Guayaquil SC | - | Independiente Juniors | 1:2 | ||||
| 12. Jornada | 06.06.2021 | Guayaquil SC | - | Gualaceo SC | 1:1 | ||||
| 17. Jornada | 23.06.2021 | Chacaritas FC | - | Guayaquil SC | 2:3 | ||||
| 18. Jornada | 27.06.2021 | Guayaquil SC | - | Liga de Portoviejo | 2:1 | ||||
| 19. Jornada | 04.07.2021 | Atlético Porteño | - | Guayaquil SC | 4:1 | ||||
| 21. Jornada | 11.07.2021 | Gualaceo SC | - | Guayaquil SC | 2:0 | ||||
| 22. Jornada | 16.07.2021 | Independiente Juniors | - | Guayaquil SC | 1:2 | ||||
| 23. Jornada | 18.07.2021 | Guayaquil SC | - | Cumbayá | 1:2 |  |
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| 25. Jornada | 29.07.2021 | Guayaquil SC | - | Chacaritas FC | 0:0 | ||||
| 31. Jornada | 09.09.2021 | Cumbayá | - | Guayaquil SC | 1:0 | ||||
| 33. Jornada | 22.09.2021 | Chacaritas FC | - | Guayaquil SC | 4:1 | ||||
| 35. Jornada | 06.10.2021 | Atlético Santo Domingo | - | Guayaquil SC | 1:1 | ||||
| 36. Jornada | 13.10.2021 | Guayaquil SC | - | Atlético Porteño | 4:3 |
Ecuador