| 1. Jornada | 08.01.2017 | UANL Tigres | - | Santos Laguna | 0:0 | ||||
| 2. Jornada | 16.01.2017 | Santos Laguna | - | CD Veracruz | 2:1 | ||||
| 3. Jornada | 22.01.2017 | Monarcas Morelia | - | Santos Laguna | 1:1 | ||||
| 4. Jornada | 30.01.2017 | Santos Laguna | - | Puebla FC | 2:0 | ||||
| 5. Jornada | 05.02.2017 | Deportivo Guadalajara | - | Santos Laguna | 1:1 | ||||
| 6. Jornada | 13.02.2017 | Santos Laguna | - | Cruz Azul | 2:2 | ||||
| 7. Jornada | 19.02.2017 | Club León | - | Santos Laguna | 2:2 | ||||
| 8. Jornada | 27.02.2017 | Santos Laguna | - | Club Necaxa | 2:2 | ||||
| 9. Jornada | 05.03.2017 | Pumas UNAM | - | Santos Laguna | 2:1 | ||||
| 11. Jornada | 18.03.2017 | Club Tijuana | - | Santos Laguna | 1:1 | ||||
| 12. Jornada | 03.04.2017 | Santos Laguna | - | Gallos Blancos | 1:0 | ||||
| 13. Jornada | 10.04.2017 | Santos Laguna | - | CF Pachuca | 1:0 | ||||
| 10. Jornada | 13.04.2017 | Santos Laguna | - | CF Monterrey | 2:2 |  |
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| 14. Jornada | 16.04.2017 | Atlas Guadalajara | - | Santos Laguna | 1:1 | ||||
| 15. Jornada | 24.04.2017 | Santos Laguna | - | CF América | 2:1 | ||||
| 16. Jornada | 30.04.2017 | Chiapas FC | - | Santos Laguna | 2:2 | ||||
| 17. Jornada | 08.05.2017 | Santos Laguna | - | Deportivo Toluca | 2:2 |
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