| 1. Jornada | 23.07.2017 | Lobos BUAP | - | Santos Laguna | 2:2 |  |
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| 2. Jornada | 31.07.2017 | Santos Laguna | - | UANL Tigres | 1:1 | ||||
| 3. Jornada | 05.08.2017 | Monarcas Morelia | - | Santos Laguna | 1:1 | |
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| 4. Jornada | 14.08.2017 | Santos Laguna | - | CD Veracruz | 2:3 | ||||
| 5. Jornada | 19.08.2017 | Club Tijuana | - | Santos Laguna | 2:0 | ||||
| 7. Jornada | 27.08.2017 | Club León | - | Santos Laguna | 1:2 | ||||
| 8. Jornada | 11.09.2017 | Santos Laguna | - | Deportivo Toluca | 0:0 | ||||
| 14. Jornada | 22.10.2017 | Gallos Blancos | - | Santos Laguna | 1:2 | ||||
| 15. Jornada | 30.10.2017 | Santos Laguna | - | CF Pachuca | 2:2 | ||||
| 16. Jornada | 05.11.2017 | Pumas UNAM | - | Santos Laguna | 2:2 | ||||
| 11. Jornada | 10.11.2017 | CF Monterrey | - | Santos Laguna | 1:1 | ||||
| 17. Jornada | 20.11.2017 | Santos Laguna | - | CF América | 0:1 |
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