| 22. Jornada | 26.02.2022 | Neckarsulmer Sport-Union | - | 1. FC Bruchsal | 2:2 |  |
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| 23. Jornada | 05.03.2022 | FSV 08 Bietigheim-Bissingen | - | Neckarsulmer Sport-Union | 0:3 | ||||
| 21. Jornada | 09.03.2022 | TSV Ilshofen | - | Neckarsulmer Sport-Union | 3:0 | ||||
| 26. Jornada | 26.03.2022 | Neckarsulmer Sport-Union | - | FC Nöttingen | 0:1 | ||||
| 25. Jornada | 06.04.2022 | FV Lörrach-Brombach | - | Neckarsulmer Sport-Union | 0:2 | ||||
| 31. Jornada | 23.04.2022 | SSV Reutlingen | - | Neckarsulmer Sport-Union | 0:2 | ||||
| 32. Jornada | 27.04.2022 | Neckarsulmer Sport-Union | - | TSG Backnang | 4:1 | ||||
| 33. Jornada | 30.04.2022 | FV Ravensburg | - | Neckarsulmer Sport-Union | 0:1 | ||||
| 27. Jornada | 04.05.2022 | SV Oberachern | - | Neckarsulmer Sport-Union | 1:0 | ||||
| 34. Jornada | 07.05.2022 | Neckarsulmer Sport-Union | - | FC 08 Villingen | 1:2 | ||||
| 35. Jornada | 14.05.2022 | SV Linx | - | Neckarsulmer Sport-Union | 1:2 | ||||
| 37. Jornada | 28.05.2022 | Neckarsulmer Sport-Union | - | Sportfreunde Dorfmerkingen | 0:2 | ||||
| 38. Jornada | 04.06.2022 | 1. CfR Pforzheim | - | Neckarsulmer Sport-Union | 4:0 |
Alemania