| 17. Jornada | 18.02.2022 | NK Inter Zaprešić | - | NK Opatija | 1:0 | ||||
| 20. Jornada | 12.03.2022 | NK Opatija | - | Dinamo Zagreb II | 0:0 | ||||
| 21. Jornada | 19.03.2022 | NK Solin | - | NK Opatija | 1:0 | ||||
| 25. Jornada | 23.04.2022 | NK Opatija | - | NK Rudeš | 3:1 | ||||
| 27. Jornada | 06.05.2022 | NK Opatija | - | NK Sesvete | 1:1 | ||||
| 28. Jornada | 14.05.2022 | NK Dugopolje | - | NK Opatija | 3:2 | ||||
| 29. Jornada | 21.05.2022 | NK Opatija | - | NK Dubrava | 0:2 | ||||
| 30. Jornada | 28.05.2022 | HNK Orijent Rijeka | - | NK Opatija | 3:0 |
Croacia