| 2. Jornada | 23.03.2022 | Atlético Santo Domingo | - | Independiente Juniors | 0:1 |  |
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| 3. Jornada | 27.03.2022 | Imbabura | - | Atlético Santo Domingo | 2:0 | ||||
| 4. Jornada | 31.03.2022 | Atlético Santo Domingo | - | Manta | 2:0 | ||||
| 5. Jornada | 06.04.2022 | Búhos ULVR | - | Atlético Santo Domingo | 1:0 |  |
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| 8. Jornada | 27.04.2022 | Chacaritas FC | - | Atlético Santo Domingo | 1:0 | |
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| 9. Jornada | 05.05.2022 | Atlético Santo Domingo | - | Olmedo | 1:2 | ||||
| 10. Jornada | 13.05.2022 | Independiente Juniors | - | Atlético Santo Domingo | 1:0 |
Ecuador