| 3. Jornada | 12.09.2021 | Unionistas CF | - | Extremadura UD | 3:0 | ||||
| 4. Jornada | 17.09.2021 | Extremadura UD | - | Racing de Ferrol | 1:0 |  |
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| 5. Jornada | 26.09.2021 | Extremadura UD | - | Rayo Majadahonda | 3:2 | ||||
| 6. Jornada | 03.10.2021 | CF Talavera | - | Extremadura UD | 1:1 | ||||
| 7. Jornada | 09.10.2021 | Extremadura UD | - | Valladolid B | 1:0 | ||||
| 15. Jornada | 04.12.2021 | Extremadura UD | - | Zamora CF | 2:2 |  |
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| 16. Jornada | 12.12.2021 | UD Logroñés | - | Extremadura UD | 1:3 | |
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| 17. Jornada | 18.12.2021 | Extremadura UD | - | Real Racing | 2:4 |  |
España