| 19. Jornada | 30.01.2022 | Hércules CF | - | CF Intercity | 0:1 |  |
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| 20. Jornada | 06.02.2022 | CF Intercity | - | Real Murcia | 0:0 | ||||
| 21. Jornada | 13.02.2022 | UD Melilla | - | CF Intercity | 0:0 | ||||
| 22. Jornada | 20.02.2022 | CF Intercity | - | Águilas FC | 1:0 | ||||
| 23. Jornada | 27.02.2022 | Atlético Mancha Real | - | CF Intercity | 0:1 | |
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| 24. Jornada | 06.03.2022 | CF Intercity | - | CD Toledo | 0:0 | ||||
| 25. Jornada | 13.03.2022 | CD Marchamalo | - | CF Intercity | 2:2 | ||||
| 26. Jornada | 20.03.2022 | CF Intercity | - | Granada B | 1:0 | |
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| 27. Jornada | 27.03.2022 | CS Puertollano CF | - | CF Intercity | 0:1 | ||||
| 28. Jornada | 03.04.2022 | Mar Menor CF | - | CF Intercity | 0:1 |  |
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| 29. Jornada | 10.04.2022 | CF Intercity | - | UD Alzira | 3:0 | ||||
| 30. Jornada | 17.04.2022 | UD Socuéllamos | - | CF Intercity | 2:1 | ||||
| 31. Jornada | 24.04.2022 | CF Intercity | - | CA Pulpileño | 4:0 | ||||
| 32. Jornada | 30.04.2022 | Atlético Levante | - | CF Intercity | 0:5 | |
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| 33. Jornada | 08.05.2022 | CF Intercity | - | CD El Ejido 2012 | 0:1 | ||||
| 34. Jornada | 15.05.2022 | CF La Nucía | - | CF Intercity | 0:0 |
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