| 1. Jornada | 05.01.2019 | Puebla FC | - | Cruz Azul | 1:1 | ||||
| 2. Jornada | 13.01.2019 | Deportivo Toluca | - | Puebla FC | 2:0 |  |
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| 4. Jornada | 26.01.2019 | CD Veracruz | - | Puebla FC | 0:1 | |
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| 5. Jornada | 02.02.2019 | Puebla FC | - | Club Necaxa | 1:4 |  |
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| 6. Jornada | 09.02.2019 | Atlas Guadalajara | - | Puebla FC | 1:2 | ||||
| 7. Jornada | 16.02.2019 | Puebla FC | - | CF Pachuca | 1:1 | ||||
| 8. Jornada | 24.02.2019 | CF Monterrey | - | Puebla FC | 0:0 | ||||
| 9. Jornada | 05.03.2019 | Puebla FC | - | Gallos Blancos | 1:0 | ||||
| 10. Jornada | 10.03.2019 | CF América | - | Puebla FC | 1:0 | |
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| 11. Jornada | 16.03.2019 | Puebla FC | - | Pumas UNAM | 1:0 | ||||
| 12. Jornada | 01.04.2019 | Lobos BUAP | - | Puebla FC | 0:4 | ||||
| 13. Jornada | 06.04.2019 | Puebla FC | - | Monarcas Morelia | 1:1 | ||||
| 14. Jornada | 13.04.2019 | Puebla FC | - | Club León | 0:3 | ||||
| 15. Jornada | 21.04.2019 | Deportivo Guadalajara | - | Puebla FC | 1:3 | ||||
| 16. Jornada | 27.04.2019 | Puebla FC | - | UANL Tigres | 1:1 | |
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| 17. Jornada | 05.05.2019 | Club Tijuana | - | Puebla FC | 4:0 |  |
México