| 2. Jornada | 15.01.2022 | Atlas Guadalajara [Sub 20] | - | Atlético San Luis [Sub 20] | 1:3 |  |
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| 3. Jornada | 20.01.2022 | Atlético San Luis [Sub 20] | - | FC Juárez [Sub 20] | 7:1 | ||||
| 4. Jornada | 05.02.2022 | CF América [Sub 20] | - | Atlético San Luis [Sub 20] | 0:1 | |
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| 5. Jornada | 12.02.2022 | Atlético San Luis [Sub 20] | - | Deportivo Toluca [Sub 20] | 4:1 | ||||
| 6. Jornada | 19.02.2022 | UANL Tigres [Sub 20] | - | Atlético San Luis [Sub 20] | 1:1 |  |
México