| 2. Jornada | 08.08.2021 | Municipal Limeño | - | Luis Ángel Firpo | 1:1 |  |
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| 3. Jornada | 11.08.2021 | Once Municipal | - | Municipal Limeño | 4:1 | ||||
| 4. Jornada | 15.08.2021 | Municipal Limeño | - | FAS | 0:3 | ||||
| 5. Jornada | 22.08.2021 | Isidro Metapán | - | Municipal Limeño | 1:0 | ||||
| 6. Jornada | 25.08.2021 | Municipal Limeño | - | Atlético Marte | 1:2 | |
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| 7. Jornada | 29.08.2021 | Santa Tecla FC | - | Municipal Limeño | 1:1 | ||||
| 8. Jornada | 12.09.2021 | Municipal Limeño | - | CD Águila | 1:0 | ||||
| 9. Jornada | 15.09.2021 | Jocoro FC | - | Municipal Limeño | 3:1 | ||||
| 10. Jornada | 19.09.2021 | AD Chalatenango | - | Municipal Limeño | 1:1 | |
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| 12. Jornada | 02.10.2021 | Municipal Limeño | - | Alianza | 0:3 | |
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| 14. Jornada | 09.10.2021 | Municipal Limeño | - | Once Municipal | 1:1 | ||||
| 15. Jornada | 24.10.2021 | FAS | - | Municipal Limeño | 2:1 | ||||
| 21. Jornada | 21.11.2021 | Municipal Limeño | - | AD Chalatenango | 0:3 | ||||
| 22. Jornada | 27.11.2021 | Platense Zacatecoluca | - | Municipal Limeño | 0:1 | |
El Salvador