| 1. Jornada | 15.08.2021 | SC Cambuur | - | FC Groningen | 1:2 | ||||
| 2. Jornada | 21.08.2021 | FC Groningen | - | FC Utrecht | 0:0 | ||||
| 3. Jornada | 28.08.2021 | PSV | - | FC Groningen | 5:2 | ||||
| 6. Jornada | 22.09.2021 | FC Groningen | - | Vitesse | 0:1 | ||||
| 7. Jornada | 25.09.2021 | AFC Ajax | - | FC Groningen | 3:0 | ||||
| 8. Jornada | 01.10.2021 | FC Groningen | - | FC Twente | 1:1 | ||||
| 9. Jornada | 17.10.2021 | Sparta Rotterdam | - | FC Groningen | 1:1 | ||||
| 10. Jornada | 24.10.2021 | FC Groningen | - | AZ Alkmaar | 2:0 | ||||
| 11. Jornada | 31.10.2021 | NEC Nijmegen | - | FC Groningen | 3:0 |  |
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| 12. Jornada | 07.11.2021 | FC Groningen | - | RKC Waalwijk | 1:1 | ||||
| 13. Jornada | 21.11.2021 | Go Ahead Eagles | - | FC Groningen | 0:1 | ||||
| 14. Jornada | 27.11.2021 | Fortuna Sittard | - | FC Groningen | 1:4 | ||||
| 15. Jornada | 03.12.2021 | FC Groningen | - | PEC Zwolle | 1:1 | ||||
| 16. Jornada | 12.12.2021 | FC Groningen | - | Feyenoord | 1:1 | ||||
| 17. Jornada | 18.12.2021 | Heracles Almelo | - | FC Groningen | 4:2 | ||||
| 18. Jornada | 21.12.2021 | AZ Alkmaar | - | FC Groningen | 1:0 | |
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| 19. Jornada | 16.01.2022 | FC Groningen | - | PSV | 0:1 | ||||
| 20. Jornada | 22.01.2022 | Vitesse | - | FC Groningen | 1:3 | |
Países Bajos