| 2. Jornada | 12.01.2022 | CF Monterrey II | - | Cimarrones de Sonora | 1:0 |  |
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| 4. Jornada | 27.01.2022 | CF Monterrey II | - | Alebrijes de Oaxaca | 2:0 | |
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| 5. Jornada | 30.01.2022 | Club Celaya | - | CF Monterrey II | 2:1 | |
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| 6. Jornada | 03.02.2022 | CF Monterrey II | - | Atlante | 0:1 |  |
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| 8. Jornada | 16.02.2022 | CF Monterrey II | - | Correcaminos UAT | 3:3 | ||||
| 10. Jornada | 03.03.2022 | CF Monterrey II | - | Venados FC | 3:3 | ||||
| 13. Jornada | 24.03.2022 | Leones Negros | - | CF Monterrey II | 0:0 | ||||
| 17. Jornada | 16.04.2022 | Tapatío | - | CF Monterrey II | 1:2 | |
México