| 1. Jornada | 01.08.2021 | Once Municipal | - | CD Águila | 2:2 | ||||
| 3. Jornada | 11.08.2021 | Once Municipal | - | Municipal Limeño | 4:1 | ||||
| 6. Jornada | 25.08.2021 | Luis Ángel Firpo | - | Once Municipal | 2:2 |  |
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| 7. Jornada | 29.08.2021 | AD Chalatenango | - | Once Municipal | 1:2 | ||||
| 5. Jornada | 10.09.2021 | Alianza | - | Once Municipal | 1:0 | ||||
| 8. Jornada | 12.09.2021 | Once Municipal | - | FAS | 1:3 | ||||
| 9. Jornada | 16.09.2021 | Isidro Metapán | - | Once Municipal | 0:1 | |
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| 10. Jornada | 19.09.2021 | Once Municipal | - | Atlético Marte | 0:0 | ||||
| 11. Jornada | 26.09.2021 | Santa Tecla FC | - | Once Municipal | 0:1 | ||||
| 12. Jornada | 03.10.2021 | CD Águila | - | Once Municipal | 1:2 | ||||
| 14. Jornada | 09.10.2021 | Municipal Limeño | - | Once Municipal | 1:1 | ||||
| 13. Jornada | 17.10.2021 | Once Municipal | - | Jocoro FC | 2:2 | ||||
| 15. Jornada | 24.10.2021 | Once Municipal | - | Platense Zacatecoluca | 1:1 | ||||
| 16. Jornada | 30.10.2021 | Once Municipal | - | Alianza | 2:3 | ||||
| 22. Jornada | 27.11.2021 | Once Municipal | - | Santa Tecla FC | 4:3 |
El Salvador